Hello all, and welcome back to another post! This is the third article in a series about folk illness and medical anthropology, but it will go more in-depth on the subject than the previous articles have. Shifting from a focus on Latin American cultures and popular folk illnesses in their cultures, this article will focus on a range of ethnic groups and how they describe asthma symptoms.
Introduction
You may be asking yourself, why asthma? Asthmatic symptoms can be induced by methacholine, a drug used in the methacholine challenge test. Working as a non-specific cholinergic agonist, the drug stimulates muscarinic receptors in the lungs to narrow, or “bronchoconstrict”, the airways in a way similar to asthma. In the classic methacholine challenge, a patient’s standard lung function is measured before they are administered increasing doses of methacholine through a nebulizer. The doses stop once the patient’s airways begin to narrow, and if one’s lung functionality drops 20% during the low-dosage phase, the individual likely suffers from asthma due to airway hyperresponsiveness. In a number of the studies I will reference, methacholine is used both in the methacholine challenge test to test for asthma and as a simulator of asthmatic symptoms. Due to its simulatability with this medication, asthma is the perfect sickness to measure cultural differences in illness description.

Research on Patient Reporting Styles
A multitude of studies looking into the phenomenon of different reporting styles have been conducted over the years. Firstly, a study conducted by Gemma et al. induced asthma symptoms in a population of White and African American participants in Northern California using the methacholine challenge to study the manner in which they would report symptoms. The results show that African Americans used upper-airway word descriptors such as “tight throat”, “scared-agitated”, “voice tight”, and “itchy throat”, among others. Conversely, White participants tended to use lower airway and chest-wall descriptors such as “deep breath”, “light-headed”, “out of air”, and “hurts to breathe” (Gemma et al.). Before interpreting these results, it is important to note that African Americans required a significantly lower dose of methacholine to achieve a 30% drop in cardiovascular function, meaning that their group could experience asthma with less provocation than other ethnic groups. The disparity in the levels at which the disease is experienced means that other differences, such as how the condition is experienced, could affect reporting styles. Another similar study conducted by the same team (Gemma et al.) examined the effects on a more ethnically diverse population, including Hispanic, Asian-Pacific, White, and African American individuals. The results of this study were similar, showing that African Americans and Asian-Pacific Islanders used upper-airway descriptors, Hispanic individuals used both upper and lower airway descriptors, and Whites used only lower airway descriptors (Gemma et al.). Overall, these studies demonstrate the diverse reporting styles across ethnic groups and the significant differences between these styles.
Unintended Discrimination
A quick search on the popular LLM-powered clinical support tool OpenEvidence tells physicians that the top symptoms of asthma are wheezing, cough, and shortness of breath. Problems arise when considering the differences between semantics of illness in the context of artificial intelligence (AI)-powered diagnostic tools. If you are not familiar with new developments in medical AI technology, you can read about them here. In brief, AI-powered medical care is rapidly advancing, but to ensure that new intelligent assistants can serve all patients equally, misdiagnoses must be prevented. I previously conducted a small-scale hypothesis-generating study that revealed semantic differences in illness descriptors across cultural groups, but it did not use an actual illness simulation to collect them.
The reviewed studies reveal that semantic differences still exist when symptoms are simulated. Training of medical AI models must be thorough as a result; failure to train a model on responses typical to multiple different ethnic groups can result in structural violence in the form of misdiagnoses.
If African American individuals consult medical AI programs that were trained on the data of white patients and describe their asthma in the typical style of the African American ethnic group, the AI could misinterpret the symptom reports as a different illness. Such an issue has been observed before in AI programs designed to expedite the process of hiring at large companies. A prime example of this is the company Amazon; its AI hiring assistant had to be shut down after it discriminated against women in the hiring process due to training cases being primarily those of males (Chen, np). With a multitude of factors that could each lead to the development of structural discrimination, companies developing AI-powered medical tools must take into deep consideration the culturally bound reporting styles of different ethnocultural groups.
In conclusion, awareness about ethnocultural divides in patient-provider communications is key. A perfect solution to this heaping issue has not been found, but awareness is the first step to developing a system that treats every individual equally.
References (MLA)
Hardie, Gemma, et al. “Ethnic Differences in Methacholine Responsiveness and Word Descriptors in African Americans, Hispanic-Mexican Americans, Asian-Pacific Islanders, and Whites with Mild Asthma.” Journal of Asthma, vol. 47, no. 4, 2010, pp. 388–396. PubMed, https://pubmed.ncbi.nlm.nih.gov/20528591/. Accessed 22 May 2026.
Hardie, Gemma E., et al. “Ethnic Differences: Word Descriptors Used by African-American and White Asthma Patients during Induced Bronchoconstriction.” Chest, vol. 117, no. 4, 2000, pp. 935–943. PubMed, https://pubmed.ncbi.nlm.nih.gov/10767221/. Accessed 22 May 2026
Chen, Zhisheng. “Ethics and Discrimination in Artificial Intelligence-Enabled Recruitment Practices.” Humanities and Social Sciences Communications, vol. 10, 2023, article no. 567, Springer Nature, https://doi.org/10.1057/s41599-023-02079-x. Accessed 27 May 2026.


